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Publications
Competition of bacteriophage polypeptides with native replicase proteins for binding to the DNA sliding clamp reveals a novel mechanism for DNA replication arrest in Staphylococcus aureus
- Molecular Microbiology, November 2006
A new class of small molecule RNA polymerase inhibitors with activity against Rifampicin-resistant Staphylococcus aureus
- Bioorganic & Medicinal Chemistry Letters, September 2006
Triaminotriazine DNA helicase inhibitors with antibacterial activity
- Bioorganic & Medicinal Chemistry Letters, March 2006
Comparative Genomic Analysis of 18 Pseudomonas aeruginosa Bacteriophages
- Journal of Bacteriology, February 2006.
Novel non-nucleobase inhibitors of S. aureus DNA polymerase IIIC
- Bioorganic & Medicinal Chemistry Letters, February 2006.
Antimicrobial drug discovery through bacteriophage genomics.
- Nature Biotechnology, 2004.
The complete genomes and proteomes of 27 Staphylococcus aureus bacteriophages.
- Proceedings of the National Academy of Sciences, 2005.
Presentations
Comparative Efficacy of Rifabutin and Gatifloxacin in the Rat Osteomyelitis Model
- Poster presented at the ASM General Meeting 2007, Toronto, Canada, May 2007.
Efficacy of Oritavancin in a Murine Model of Bacillus anthracis Spore Inhalation Anthrax
- Poster presented at the ASM General Meeting 2007, Toronto, Canada, May 2007.
Effect of Polysorbate-80 on Oritavancin Binding to Plastic Surfaces � Implications for Susceptibility Testing
- Poster presented at the 17th Annual European Congress of Clinical and
Chemotherapy (ECCMID), Munich, Germany, March-April 2007.
Influence of Polysorbate-80 on Susceptibility of Gram-positive Bacteria to Oritavancin
- Poster presented at the 17th Annual European Congress of Clinical and
Chemotherapy (ECCMID), Munich, Germany, March-April 2007.
Efficacy of oritavancin in a mouse model of Streptococcus pneumoniae pneumonia
- Poster presented at the 17th Annual European Congress of Clinical and
Chemotherapy (ECCMID), Munich, Germany, March-April 2007.
Oritavancin Kills Staphylococcus aureus in Slow-growing Planktonic
and Biofilm States
- Poster presented at the 46th Annual Interscience Conference on Antimicrobial Agents
and Chemotherapy (ICAAC), San Francisco, Sept. 2006.
Comparative In Vitro Potency of Oritavancin, Teicoplanin, and Vancomycin
against Glycopeptide-Susceptible and -Resistant Gram-Positive Organisms
- Poster presented at the 46th Annual Interscience Conference on Antimicrobial Agents
and Chemotherapy (ICAAC), San Francisco, Sept. 2006.
Oritavancin Demonstrates Rapid and Sustained Bactericidal Activity
in the Rat Granuloma Pouch Model of Staphylococcus aureus Infection
- Poster presented at the 46th Annual Interscience Conference on Antimicrobial Agents
and Chemotherapy (ICAAC), San Francisco, Sept. 2006.
Oritavancin Disrupts Transmembrane Potential and Membrane Integrity
Concomitantly with Cell Killing in Staphylococcus aureus and
Vancomycin-Resistant Enterococci
- Poster presented at the 46th Annual Interscience Conference on Antimicrobial Agents
and Chemotherapy (ICAAC), San Francisco, Sept. 2006.
Phage-Inspired Discovery of Small-Molecule Antibiotics RNA Transcription
- Presented at the Enzyme Inhibitors and Drug Design Symposia
at the 89th Canadian Chemistry Conference and Exhibition, Halifax, NB, May 30, 2006.
Discovery of Small Molecule Inhibitors of S. aureus, RNA Transcription
- Presented in Symposium 190/M (Using Phages to Develop Novel Antimicrobials and Therapies)
at the American Society for Microbiology (ASM) 106th General Meeting, Orlando, FL, May 21-25, 2006.
Antimicrobial Drug Discovery Through Bacteriophage Genomics
- Presented at the Department of Microbiology and Immunology,
McGill University, Montreal, QC, May 18, 2006.
Phage-Inspired Discovery of Small-Molecule Antibiotics.
- Presented at the 11th Annual Antibacterial Drug Discovery & Development Summit,
Princeton, NJ, April 10-11, 2006.
The Primary Sigma Factor of
Staphylococcus aureus: From Target Identification to Isolation
of Inhibitors of the RNA Polymerase Holoenzyme.
- Poster presented at the 45th Annual Interscience Conference on Antimicrobial Agents
and Chemotherapy (ICAAC), Washington, D.C., Dec. 2005.
Bacteriophage Proteins G1ORF240 and TwORF168
Validate the DNA Sliding Clamp of Staphylococcus aureus for Inhibitor Screening.
- Poster presented at the 45th Annual ICAAC, Washington, D.C., Dec. 2005.
A New Class of Small Molecule RNA Polymerase
Inhibitors with Activity Against S. aureus.
- Poster presented at the 45th Annual ICAAC, Washington, D.C., Dec. 2005.
Antibacterial Drug Discovery and Development
Summit.
- Talk presented at the 9th Annual Antibacterial Drug Discovery and Development Summit,
Cherry Hill, NJ, March 2004.
Impact of Bacteriophage Genomics on Target Identification and
Validation for Antibacterial Discovery.
- Poster presented at the Society for Biomolecular Screening (SBS) 9th Annual Conference and
Exhibition, Portland, Oregon, Sept. 2003.
Antibacterial discovery using
phage-validated, novel targets.
- Poster presented at the 43rd Annual ICAAC, Chicago, Illinois, Sept. 2003.
From phage genomics to antimicrobial drug discovery.
- Poster presented at the 15th Annual Evergreen Phage Biology Meeting, Olympia, Washington, July 2003.
Integration of phage genomics
with target identification and HTS-a novel approach to drug discovery.
- Poster presented at the SBS 8th Annual Conference and Exhibition, The Hague, The Netherlands,
Sept. 2002.
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